An understanding of cells and cell behavior is a critically important component of disease diagnosis and treatment. But some diseases can be complex in nature, with a variety of factors and circumstances impacting their emergence and severity.Effective disease analysis often requires an understanding that goes beyond isolated cell behavior.
Genes, the environments in which cell processes operate, the impact of patient characteristics, and racial and ethnic variables all can have an important impact.An understanding of the signals and symptoms of alterations in cellular processes is a critical step in the diagnosis and treatment of many diseases.
For APRNs, this understanding can also help educate patients and guide them through their treatment plans.In this Assignment, you examine a case study and analyze the symptoms presented.
In 1-2 pages, you will answer the questions provided following the case scenario. You must use current evidence-based resources to support your answers. Follow APA guidelines. Follow the grading rubric.Case Study 2: Advanced Pathophysiology of Acute Myelogenous Leukemia (AML)A 45-year-old male presents to the hematology clinic with symptoms of progressive fatigue,frequent bruising, and recurrent nosebleeds over the past few weeks. On physical examination,he appears pale and has petechiae on his lower extremities. Blood tests reveal a white blood cellcount of 50,000/mm³ with 60% blasts, hemoglobin of 8.5 g/dL, and platelets of 25,000/mm³. Abone marrow biopsy confirms the diagnosis of AML, showing hypercellularity with 70%myeloblasts. Cytogenetic analysis reveals a FLT3-ITD mutation, placing him in the intermediate-risk category.In 1 -2 pages, answer the questions below in detail. You must use current evidence-basedresources to support your answers. Follow APA guidelines. Follow the grading rubric.
Questions:1. What is the primary cellular abnormality in AML?
2. How does the accumulation of leukemic blasts affect normal hematopoiesis?
3. What role do genetic mutations play in the development of AML?
4. Why do patients with AML often present with symptoms like fatigue, infections, andbleeding?
5. What is the significance of Auer rods in the diagnosis of AML?
6. What is the impact of AML on the immune system
7.How do treatment strategies target the pathophysiological mechanisms of AML?
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